Tangential Flow Filtration (TFF) is a widely used biopharmaceutical technology focused on process development and scale-up. Take a closer look at our PureTec II automated bench-scale TFF pumps and discover how they optimize filtration stability, efficiency, and product retention in TFF operations. (PureTec II currently available in N.A. only)

When developing a biopharmaceutical manufacturing process an R&D or process development team may fall into the trap of developing a process in the lab which is difficult to scale to work with larger volumes in production.
 

As single-use technology has become more established in biopharmaceutical manufacturing, it has driven the need for greater process control and the use of single-use automation has grown. But why has automation not been more widely adopted in single-use processes and what benefits can be realized?

Any contamination of a biopharmaceutical production process is to be avoided for obvious quality, safety and economic reasons. However, once a contamination occurs rapid detection and elimination is important to prevent further spread and higher decontamination costs.
 

While single-use technology (SUT) offers a number of advantages, there are also factors that must be considered including the presence of extractables and leachables. Learn how to decide what is right for your processes.


 

This article examines the product development cycle of a system for bulk filtration of active pharmaceutical ingredients (APIs), how this development progressed from generation one to two, and the lessons learned along the way.

 

Single-use technology plays a part in nearly all bioproduction processes, but challenges remain that are serious enough to delay or even stop its use, which means increased time and cost for lifesaving biopharmaceutical products. Of the existing challenges, which five are the most critical?